The Select Series 6 Update 1 version due out soon is the first version of AECOsim Building Designer that has been tested to work with Windows 10.
However, some users who have tried to run SS6 on Windows 10 have reported seeing the following error when starting AECOsim Building Designer:
If you see this error, turn the User Account Control Settings (UAC) off (Never Notify) temporarily and run a Repair on the product installation (Settings - Programs - Add/Remove Programs) and then reboot the machine and see if you still get the errors.
If the problem persists, the solution may be found in this blog article -