Whenever OpenBuildings Designer Update 6 or AECOsim Building Designer V8i Ss6 are opened on a specific workstation, they will crash. This same user was able to open both products before on this same machine and can still open them when logged on to a different workstation, so it doesn't seem to be a user profile or permissions related issue. However, if a different user logs on to this workstation then both applications will crash. We've tried reinstalling them, generating new preference files, cleared the \temp folder, etc., but nothing has helped.
It was discovered that user had installed PKPM analysis software on this machine, and something in that installation was conflicting with both OpenBuildings Designer Update 6 and AECOsim Building Designer Ss6. Uninstalling it allowed both applications to run correctly. Based on the exception.log file the failure was at a core/platform level and included lines referring to "StrongNameSignatureVerification" which relates to signature validation in fully trusted .NET domains. See this Microsoft article for more information.