Optimizing Your Calibration

Hello!

I am in the process of calibrating several pressure planes within a water system and I have a question about the best strategy to using Darwin Calibrator.

I have seen it suggested to do several optimized runs while calibrating the same pressure plane. For example, perhaps do an optimized run where you mess with pipe status. Then update the model with any closed/open pipes you discovered from the first run. Then run another optimized run where you alter pipe roughnesses. 

Is there an advantage to doing several optimized runs like this? I've always just done one calibration and allowed Darwin to mess with pipe status and roughness at the same time. Is it able to come up with a better solution when you break it up into several runs?

Thank you in advance for your help!