Open file read-only is permanently active.Suddenly in MicroStation Manager the "Open as read-only" check box is permanently active.It must be deactivated to open a file in edit mode.
Remove -restoredefaults from target.MicroStation has been set to defaults:http://communities.bentley.com/products/microstation/w/microstation__wiki/8671.restore-microstation-to-factory-defaults
Afterwards -restoredefaults has not been removed from target.After removing it from target the read-only check box isn't activated anymore when starting MicroStation Manager.