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User Preferences include the Operation > Compress File on Exit option.
If selected it will only compact the file's structured storage removing elements marked for deletion.
It will not include any of the compress options found in the Compress Options dialog.
Search MicroStation help using "Compress Options Dialog" (include the quotation marks to search for the phrase) for details of the options available and related topics.
Please Note : If you access files over network and/or do not have a good file back-up system in place, then do not use this option. Better options would be to take a back-up of the file and then manually compress (File > Compress > Design)
Compress Options
http://communities.bentley.com/other/old_site_member_blogs/peer_blogs/b/marc_thomass_blog/archive/2014/04/14/site-standards-3-user-preference-seeds
An earlier Ask Inga tip:
http://communities.bentley.com/communities/other_communities/askinga/w/askinga/configure-your-compress-options.aspx