How to find worst case of concentrated forces?


I am modelling a pipe system where concentrated forces and moments are applied (in Gravity case) at the interface connection points. Is there a way to check which sign combination that gives the worst result regarding stresses and restraint forces? F.ex. for applied F1, F2, M3, M4, the worst combination could be -F1, +F2, -M3, +M4, etc.

Appreciate any answer.