It is best practice to use Grid and Snap locks when drafting. Not doing so can cause cells to arrange incorrectly (off grid) or lines to not be orthogonal.
MicroStation offers several ways to set Locks. File menu: Settings->Locks-Full, Tools->Tool Boxes (Ctrl+T) or from the Status Bar icons (panel at the bottom of MicroStation).
I like using the Snap and Grid icons on the Status bar. Using the Locks dialog could clutter the screen.
Steve - Great point. I would also like to mention the use of AccuDraw. This tool is great for aligning components and locking an axis with a simple tap of the Enter key. Check out the Ask Inga BE Community Wiki site for more on the use of Accudraw.
Here's to your success,
Tony DeRosa
Bentley Plant