On logging in to ProjectWise for the first time the creation of a local folder is saying "no permissions"

Jayne, it would be helpful if there was a bit more information.  I'm assuming that this is a problem for you, perhaps you cannot sign into a ProjectWise datasource?

My guess would be that your ProjectWise user account has a working directory defined, but it doesn't exist, and your OS user does not have write access to that location to create the non-existent directory.  If you aren't being prompted to change your working directory, then it is probably "locked down" so that you can't change it.

Someone will need to give you write access to that location so that you can create the missing directory, or create it for you (and grant you write access to that directory and sub-directories), or change your ProjectWise user settings so that you can specify a different location for your working directory.