Error 50176 Cannot start application for the specified document. Check your program associations. Operating system function call failed.
It happens when Projectwise client is launched without elevated access rights(no administrator rights), but targeted software requires elevated permissions to run.
Make sure targeted software can be ran without elevated permissions.
In services on the machine, make sure the RPC Endpoint Mapper service is running
A user reports that the problem occurred when the users account was migrated to exchange 2016. The solution was to create the user a new local mail profile.