Individual Annotations Not Permanently Deleting

Hi - I have created and applied a profile annotation group. It works exactly as I would like when placing labels. 

I need to delete/move a few of the annotations for clarity. When I delete or move the few annotations, the tools work as I would like. However, when I reopen or refresh the file the annotations return to their original positions.

This has never happened before. Why can I not permanently delete or move individual text annotations?